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Evidence-Based Medicine 2005; 10:12
© 2005 BMJ Publishing Group Ltd.

Therapeutics

Review: fluoxetine, orlistat, and sibutramine modestly reduce weight in type 2 diabetes

Norris SL, Zhang X, Avenell A, et al. Efficacy of pharmacotherapy for weight loss in adults with type 2 diabetes mellitus: a meta-analysis. Arch Intern Med 2004;164:1395–404.[Abstract/Free Full Text]

Q In patients with type 2 diabetes mellitus, what is the efficacy of pharmacotherapy for weight loss?

Clinical impact ratings GP/FP/Primary care *****{star}{star} IM/Ambulatory care *****{star}{star} Endocrine *****{star}{star}

Key Words: anti-obesity agents • appetite depressants • fluoxetine • weight loss • diabetes mellitus • type 2

The first 150 words of the full text of this article appear below.

METHODS
{ebmcmptrbooks.f1}Data sources: Medline (1966 to September 2002), EMBASE/Excerpta Medica (1974 to September 2002), CINAHL (1982 to September 2002), Web of Science (1981 to September 2002), Biosis (1970 to September 2002), International Pharmaceutical Abstracts (1970 to September 2002), Cochrane Library (Issue 3, 2002), Cochrane Register of Controlled Trials (Issue 3, 2002), key journals, bibliographies of relevant studies, and contact with experts and drug manufacturers.

{ebmmgnfyglas.f1}Study selection and assessment: published and unpublished studies that used pharmacotherapy as the primary strategy for weight loss in adults with type 2 diabetes and had weight as an outcome. The drugs evaluated were centrally acting appetite suppressants, drugs with a peripheral effect on appetite, drugs that affect nutrient partitioning, and drugs that increase thermogenesis. Drugs withdrawn from the US market or unavailable in the US, investigational drugs and dietary supplements, and metformin and acarbose were excluded. Studies were assessed for quality.

{ebmruler.f1}Outcomes: changes in weight and . . . [Full text of this article]

Christopher D Byrne, FRCP, FRCPath, PhD1, Sarah Wild, MRCP, MRCGP, MFPHM, PhD2

1 Southampton General Hospital
Southampton, UK
2 University of Edinburgh
Edinburgh, UK






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