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Ginger was equivalent to pyridoxine hydrochloride (vitamin B6) for reducing nausea and vomiting in pregnancy

Clinical impact ratings FP/GP/Obstetrics Obstetrics

Key Words: ginger • nausea • pregnancy • vitamin B6 • vomiting

The first 150 words of the full text of this article appear below.

METHODS
Design: randomised controlled equivalence trial.

Allocation: concealed.^*

Blinding: blinded (patients, healthcare providers, and data collectors).^*

Follow up period: 3 weeks.

Setting: a hospital in Adelaide, South Australia, Australia.

Patients: 291 women who were 8–16 weeks pregnant (confirmed by ultrasonography). Exclusion criteria: signs of clinical dehydration, allergy to ginger or pyridoxine, or suspicion that symptoms were not related to pregnancy.

Intervention: women were allocated to ginger, 350 mg capsule 3 times daily (n = 146), or pyridoxine, 25 mg capsule 3 times daily (n = 145), for 3 weeks.

Outcomes: nausea, dry retching, and vomiting (Rhodes Index of Nausea and Vomiting Form 2; score 0–12, with higher scores indicating more symptoms); change in health status (MOS 36 Short Form Health Survey); and pregnancy outcomes.

Patient follow up: 81%.

MAIN RESULTS
Treatment groups did not differ for overall reduction of symptoms (table). Ginger was therapeutically equivalent to pyridoxine for improving nausea (mean difference . . . [Full text of this article]

Charissa Fotinos, MD

University of Washington
Seattle, Washington, USA