HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Smith, D. A Search for Related Content PubMed Articles by Smith, D. A

Picotamide reduced all cause mortality more than aspirin in type 2 diabetes mellitus and peripheral arterial disease

Clinical impact ratings IM/Ambulatory care Haematology Endrocrine

Key Words: phthalic acids • vascular diseases • diabetes mellitus (type 2)

The first 150 words of the full text of this article appear below.

METHODS
Design: randomised placebo controlled trial (Drug Evaluation in Atherosclerotic Vascular Disease in Diabetics [DAVID] study).

Allocation: concealed.^*

Blinding: blinded (clinicians, patients, data collectors, outcome assessors, and data safety and monitoring committee).^*

Follow up period: 24 months.

Setting: 86 centres in Italy.

Patients: 1209 patients who were 40–75 years of age (mean age 64 y, 73% men) with type 2 diabetes for 5 years and PAD (2 of intermittent claudication for >2 mo, loss of posterior tibial pulse in the foot, ankle/arm pressure ratio <0.90 or >1.30 in the posterior or anterior tibial artery of the foot, amputation or reconstructive surgery in patients with previous intermittent claudication, or angioplasty). Exclusion criteria included myocardial infarction (MI), stroke, or unstable angina in the previous 6 months; severe neurological or mental deficits; severe comorbid conditions that would limit life expectancy to <2 years; serum creatinine >2.0 mg/dl (176 µmol/l); pregnancy; severe uncontrolled hypertension; . . . [Full text of this article]

Donald A Smith, MD, MPH

Mount Sinai School of Medicine, New York, New York, USA