A haemoglobin concentration of 140 g/l was associated with a lower mortality risk than concentrations <=120 g/l in older women with disabilities

doi:10.1136/ebm.10.3.90

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Evidence-Based Medicine 2005; 10:90
© 2005 BMJ Publishing Group Ltd.

Aetiology

A haemoglobin concentration of 140 g/l was associated with a lower mortality risk than concentrations $<=$ 120 g/l in older women with disabilities

Chaves PH, Xue QL, Guralnik JM, et al. What constitutes normal hemoglobin concentration in community-dwelling disabled older women? J Am Geriatr Soc 2004;52:1811–6.[CrossRef][Medline]

Q Are haemoglobin (Hb) concentrations associated with mortality risk in older, community dwelling women with disabilities?

Clinical impact ratings GP/FP/Primary care $*$ $*$ $*$ $*$ $*$ $*$ ${star}$ Haematology $*$ $*$ $*$ $*$ ${star}$ ${star}$ ${star}$ Geriatrics $*$ $*$ $*$ $*$ $*$ ${star}$ ${star}$

Key Words: haemoglobins • mortality • disabled persons

The first 150 words of the full text of this article appear below.

METHODS
Design: cohort study (Women’s Health and Aging Study I).

Setting: Baltimore, Maryland, USA.

Patients: 686 women $>=$ 65 years of age (mean age 78 y, 72% white), who hada Mini-Mental State Examination score $>=$ 18 and self reported difficultyperforming activities in $>=$ 2 physical function domains.

Risk factors: Hb concentrations.

Outcomes: all cause mortality after a maximum of 6 years of follow up(median 5 y).

MAIN RESULTS
Cumulative all cause mortality was 31%. A non-linear relationexisted between Hb and mortality, with highest mortality riskat extreme Hb concentrations and lowest risk in intermediateHb concentrations. Mildly low Hb concentrations of 110 and 115g/l were associated with greater mortality risk than an Hb concentrationof 120 g/l, even after controlling for major chronic diseaseburden indicators, whereas mid-normal Hb concentrations of 130g/l and 140 g/l were associated with lower mortality risk (table).The threshold above which the decline in . . . [Full text of this article]

Martin O’Flaherty, MD