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Evidence-Based Medicine 2006;11:11; doi:10.1136/ebm.11.1.11
Copyright © 2006 by the BMJ Publishing Group Ltd.
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Therapeutics

Vitamin E did not prevent cardiovascular disease and cancer in healthy women

Lee IM, Cook NR, Gaziano JM, et al. Vitamin E in the primary prevention of cardiovascular disease and cancer. The Women’s Health Study: a randomized controlled trial. JAMA 2005;294:56–65.[Abstract/Free Full Text]

Q In healthy women >= 45 years of age, how effective is vitamin E in preventing cardiovascular disease (CVD) and cancer?

Clinical impact ratings GP/FP/Primary care ******{star} IM/Ambulatory care *****{star}{star} Internal medicine *****{star}{star}

Key Words: cardiovascular diseases • neoplasms • {alpha} tocopherol

The first 150 words of the full text of this article appear below.

METHODS
Formula Design: randomised placebo controlled trial (Women’s Health Study [WHS], a randomised 2 x 2 factorial trial).

Formula Allocation: concealed.*

Formula Blinding: blinded {participants, healthcare providers, data collectors, and outcome assessors}{dagger}.*

Formula Follow up period: mean 10.1 years.

Formula Setting: {a mail-based trial in female health professionals in the US}{dagger}.

Formula Participants: 39 876 women >=45 years of age (mean age 55 y) without previous history of cancer (except non-melanoma skin cancer), CVD, or other major chronic illness; no history of adverse effects to aspirin; not taking aspirin or non-steroidal anti-inflammatory drugs more than once per week; not taking anticoagulants or corticosteroids; and not taking individual supplements of vitamin A, vitamin E, or ß carotene more than once per week.

Formula Intervention: vitamin E (600 IU of {alpha} tocopherol every other d) (n = 19 937) or matching placebo (n = 19 939).

Formula Outcomes: a composite end point of first major CV event (non-fatal myocardial infarction . . . [Full text of this article]

Laura Rees Willett, MD

Robert Wood Johnson Medical School
New Brunswick, New Jersey, USA


Related Article

Glossary
Evid. Based Med. 2006 11: 31. (in Glossary) [Extract] [Full Text] [PDF]





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