HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lindbaek, M. Search for Related Content PubMed PubMed Citation Articles by Lindbaek, M. Topic Collections Relevant Article

Topical chloramphenicol was not effective in children with acute infective conjunctivitis

Clinical impact ratings GP/FP/Primary care Infectious disease Paediatrics

Key Words: chloramphenical • conjunctivitis (bacterial) • conjunctivitis (viral)

The first 150 words of the full text of this article appear below.

METHODS
Design: randomised controlled trial.

Allocation: concealed.^*

Blinding: blinded (patients, healthcare providers, data collectors, outcome assessors, and data analysts).^*

Follow up period: 7 days for the primary outcome plus an extra 5 weeks to assess relapse.

Setting: 12 primary care practices in Oxfordshire, UK.

Patients: 326 children 6 months to 12 years of age who had acute infective conjunctivitis. Exclusion criteria included an allergy to chloramphenicol, use of an antibiotic (current or within the previous 48 h), evidence of severe infection, and children who were immunocompromised.

Intervention: 0.5% chloramphenicol (preservative free eye drops BP) (n = 163) or placebo (distilled water with the excipients boric acid, 1.5%, and borax, 0.3%) (n = 163). Parents were instructed to put 1 drop in each of their child’s affected eye every 2 hours for the first 24 hours when their child was awake and then 4 times daily until 48 hours after the infection . . . [Full text of this article]

Morten Lindbaek, MD

University of Oslo
Oslo, Norway

Relevant Article

Glossary
Evid. Based Med. 2006 11: 31. (in Glossary) [Extract] [Full Text] [PDF]

This article has been cited by other articles:

				K. M Qureshi, S. Robbie, S. Kashani, and P. Rose Viral infections need to be excluded from the cohort for the results to be truly meaningful * Author's reply Evid. Based Med., June 1, 2007; 12(3): 93 - 93. [Full Text] [PDF]