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Review: long term use of hormone therapy by postmenopausal women does not prevent chronic diseases

Clinical impact ratings GP/FP/Primary care Endocrine Geriatrics Gynaecology

Key Words: hormone replacement therapy • postmenopause • breast neoplasms • coronary disease • cerebrovascular accident • venous thrombosis • dementia • fractures • colorectal neoplasms

The first 150 words of the full text of this article appear below.

METHODS
Data sources: Medline, EMBASE/Excerpta Medica, Biological Abstracts, Cochrane Central Register of Controlled Trials, and Cochrane Menstrual Disorders and Subfertility Group Trials Register (to November 2004); UK National Research Register and registers from the UK National Health Service Centre for Reviews and Dissemination (to January 2004); reference lists of relevant articles; and pharmaceutical companies.

Study selection and assessment: randomised, double blind, placebo controlled trials (RCTs) that evaluated the effect of long term HT use (1 y) on death or serious chronic diseases in perimenopausal or postmenopausal women. HT consisted of oestrogen, alone or combined with progestogen, administered by oral, transdermal, subcutaneous, or intranasal routes.

Outcomes: mortality, heart disease, venous thromboembolism, stroke, transient ischaemic attack, breast cancer, colorectal cancer, ovarian cancer, endometrial cancer, gallbladder disease, cognitive function, dementia, and fractures.

MAIN RESULTS
15 RCTs (35 089 women, mean age 48–72 y) met the selection criteria. 2 arms of 1 large RCT (Women’s Health . . . [Full text of this article]

Carolyn Crandall, MD, MS

University of California, Los Angeles
Los Angeles, California, USA