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Evidence-Based Medicine 2006;11:59; doi:10.1136/ebm.11.2.59
Copyright © 2006 by the BMJ Publishing Group Ltd.
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Prognosis

Male sex, first idiopathic deep venous thrombosis, and oral contraception were risk factors for recurrent venous thrombotic events

Christiansen SC, Cannegieter SC, Koster T, et al. Thrombophilia, clinical factors, and recurrent venous thrombotic events. JAMA 2005;293:2352–61.[Abstract/Free Full Text]

Q In patients with a first deep venous thrombosis (DVT), what is the yearly recurrence rate of thrombosis, and which factors predict recurrence?

Clinical impact ratings Internal medicine ******* Haematology ******{star}

Key Words: thrombophilia • venous thrombosis

The first 150 words of the full text of this article appear below.

METHODS
Formula Design: inception cohort followed for mean 7.3 years.

Formula Setting: 3 anticoagulation clinics in the Netherlands (Leiden, Amsterdam, and Rotterdam).

Formula Patients: 474 patients <=70 years of age (mean age 45 y) who were diagnosed with a first DVT between 1 January 1988 and 30 December 1992 and participated in the Leiden Thrombophilia Study (a case control study of the aetiology of DVT). Patients who had cancer were excluded.

Formula Prognostic factors: type of first thrombotic event (idiopathic or provoked); sex; oral contraceptive use; factor V Leiden mutation; prothrombin 20210 mutation; elevated concentrations of factors VIII, IX, or XI or fibrinogen or homocysteine; and anticoagulant deficiencies.

Formula Outcomes: recurrent venous thrombotic event.

MAIN RESULTS
At mean 7.3 years, 90 patients had a recurrent thrombotic event, and the overall incidence was 2.6 per 100 patient-years (95% CI 2.1 to 3.2). Incidence was higher during the first 2 years (3.2 per 100 patient-years, CI 2.0 to 4.4) than . . . [Full text of this article]

Marcel Levi, MD

Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands






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