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Evidence-Based Medicine 2006;11:89; doi:10.1136/ebm.11.3.89
Copyright © 2006 by the BMJ Publishing Group Ltd.
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Therapeutics

Low dose iron supplementation was effective in older patients with iron deficiency anaemia

Rimon E, Kagansky N, Kagansky M, et al. Are we giving too much iron? Low-dose iron therapy is effective in octogenarians. Am J Med 2005;118:1142–7.[Medline]

Q In older patients with iron deficiency anaemia, can low dose iron supplementation safely replace conventional doses of iron?

Clinical impact ratings GP/FP/Primary care ******{star} Haematology ******* Geriatrics *****{star}{star}

Key Words: anaemia (iron deficiency) • ferrous compounds

The first 150 words of the full text of this article appear below.

METHODS
Formula Design randomised controlled trial.

Formula Allocation unclear allocation concealment.*

Formula Blinding unblinded.*

Formula Follow up period 60 days.

Formula Setting a geriatric ward in a hospital in Rehovot, Israel.

Formula Patients 90 patients >=80 years of age (mean age 85 y, 59% women) who were admitted to hospital with a diagnosis of anaemia (haemoglobin concentration 80 [5.0] to 119 g/l [7.4 mmol/l]) and ferritin concentration <40 ng/ml. Exclusion criteria were vitamin B12 deficiency, severe systemic illness, cancer, renal failure, iron therapy or blood transfusion within the previous week, coeliac disease, active known gastrointestinal blood loss, or acute infection.

Formula Intervention elemental iron, 15 mg (n = 30), 50 mg (n = 30), or 150 mg (n = 30) per day. Low iron doses (15 and 50 mg) were given as liquid ferrous gluconate in a simple syrup. The conventional iron dose (150 mg) was given as 1 tablet of 500 mg of ferrous calcium citrate taken . . . [Full text of this article]

George Ioannou, MD, MS, Cara Debley, MD

VA Puget Sound Heath Care System and University of Washington, Seattle
Washington, USA


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Glossary
Evid. Based Med. 2006 11: 95a. (in Glossary) [Extract] [Full Text] [PDF]





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