A low fat diet led to a minor weight loss at 7.5 years in postmenopausal women

doi:10.1136/ebm.11.4.109

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Evidence-Based Medicine 2006;11:109; doi:10.1136/ebm.11.4.109
Copyright © 2006 by the BMJ Publishing Group Ltd.

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Therapeutics

A low fat diet led to a minor weight loss at 7.5 years in postmenopausal women

Howard BV, Manson JE, Stefanick ML, et al. Low-fat dietary pattern and weight change over 7 years: the Women’s Health Initiative Dietary Modification Trial. JAMA 2006;295:39–49.[Abstract/Free Full Text]

Q In postmenopausal women, does a low fat diet lead to increased body weight over time?

Clinical impact ratings GP/FP/Primary care $*$ $*$ $*$ $*$ $*$ $*$ $*$ IM/Ambulatory care $*$ $*$ $*$ $*$ $*$ $*$ ${star}$ Endocrine $*$ $*$ $*$ $*$ $*$ $*$ ${star}$

Key Words: diet (fat restricted) • postmenopause

The first 150 words of the full text of this article appear below.

METHODS
Design: randomised controlled trial (Women’s Health InitiativeDietary Modification Trial).

Allocation: {concealed^*}.

Blinding: blinded (outcome assessors, {data collectors, and data analysts}).^*

Follow up period: mean 7.5 years.

Setting: 40 clinical centres in the US.

Participants: 48 835 women who were 50–79 years of age (mean age 62y, 81% white), were postmenopausal, and consumed a diet withfat intake of $>=$ 32% of daily total calories. Exclusion criteria:previous breast cancer, cancers other than non-melanoma skincancer in past 10 years, illness with predicted survival <3years, and impediments to adherence (eg, alcoholism).

Intervention: low fat dietary intervention (n = 19 541) or usual diet (n =29 294). Women in the low fat group received educational sessionsin which they were encouraged to reduce total dietary fat to20% and to eat $>=$ 5 servings of fruit and vegetables and $>=$ 6 servingsof grains per day. The educational . . . [Full text of this article]

Joel A Simon, MD, MPH

San Francisco Veterans Affairs Medical Center
San Francisco, California, USA

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Evid. Based Med. 2006 11: 127. (in Glossary) [Extract] [Full Text] [PDF]