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One study is rarely definitive, and we accumulate pieces of the puzzle of benefits and harms. In this issue is an interesting pair of articles on long acting ß agonists. The first study shows an advantage of self titration with a combination long acting ß agonist and inhaled corticosteroid—a revolutionary approach. A second shows possible harms from long acting ß agonists. Is it the specific ß agonist? Will the combination with corticosteroids prevent the possible harmful effects? The trials answer many questions but raise new uncertainties that we must accept as part of the background of practice. Meanwhile some accepted "truths" have been found wanting: humidifiers for croup and (most) lifestyle changes for reflux do not fare well.
If you are interested in a particular topic, the back issues of the EBM journal now form a superb summary of key studies in the last 6 years. If you go to EBM
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