Therapeutics
Combined budesonide and formoterol for maintenance and relief provided better asthma control than budesonide for maintenance and terbutaline for relief
Rabe KF, Pizzichini E, Ställberg B, et al. Budesonide/formoterol in a single inhaler for maintenance and relief in mild-to-moderate asthma: a randomized, double-blind trial. Chest 2006;129:246–56.
Q In patients with mild to moderate asthma, what is the efficacy and safety of budesonide plus formoterol in a single inhaler for both maintenance therapy and symptom relief compared with budesonide for maintenance therapy plus terbutaline for symptom relief?
Allergy & immunology Respirology
Key Words: asthma • bronchodilator agents • budesonide • ethanolamines
| The first 150 words of the full text of this article appear below. |
Design:
randomised controlled trial.
Allocation:
concealed (unclear).*
Blinding:
blinded (patients).*
Follow up period:
6 months.
Setting:
77 centres in Argentina, Brazil, China, Denmark, Indonesia, Norway, the Philippines, Spain, and Sweden.
Patients:
697 patients 11–79 years of age (mean age 38 y, 61% women) with asthma for 
6 months. Exclusion criteria included systemic corticosteroids or inhaled cromones in the past 30 days, recent respiratory infection, smoking history >10 pack years, and failure to complete a run in period as planned.
Intervention:
budesonide/formoterol, 80 µg/4.5 µg, 2 inhalations every evening plus budesonide/formoterol as needed (n = 355) or budesonide, 160 µg, 2 inhalations every evening plus terbutaline, 0.4 mg as needed (n = 342). As needed inhalations were limited to 
10/day.
Outcomes:
change from baseline in morning peak expiratory flow (PEF). Secondary outcomes were evening PEF, severe exacerbations, asthma symptom control, and adverse events.
Patient follow up:
639 patients (92%) (1 patient
CT Medical Group, New Haven, Connecticut, USA
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