Therapeutics
Review: vaccines prevent influenza and influenza-like illness in healthy children >2 years of age
Smith S, Demicheli V, Di Pietrantonj C, et al. Vaccines for preventing influenza in healthy children. Cochrane Database Syst Rev 2006;(1):CD004879.
Q In healthy children <16 years of age, are influenza vaccines efficacious (ie, prevent confirmed influenza) and effective (ie, prevent influenza-like illness)?
Key Words: influenza vaccines • influenza (human)
| The first 150 words of the full text of this article appear below. |
Data sources:
Medline (1966–2004), EMBASE/Excerpta Medica (1974–2004), Cochrane Library (Issue 1, 2005), Biological Abstracts (1969–2004), Science Citation Index (1974–2004), Vaccine Adverse Event Reporting System website (www.vaers.org), and vaccine manufacturers and authors of relevant studies.
Study selection and assessment:
randomised controlled trials (RCTs) or semi-randomised, cohort, and case controlled studies in any language that enrolled healthy children <16 years of age in any geographical location; compared any influenza vaccine (including unlicensed types) given independently, in any dose, preparation, or time schedule, with placebo or no intervention. 51 studies (n = 263 987) met the selection criteria: 14 RCTs and 11 cohort studies assessed vaccine efficacy and effectiveness, and 34 studies evaluated vaccine safety. Quality assessment of individual RCTs was based on the Cochrane Reviewers’ Handbook.
Outcomes:
confirmed influenza, influenza-like illness, and adverse effects in children 
18 years of age.
Meta-analyses of RCTs showed that both live attenuated vaccines and
University of Glasgow,
Glasgow, UK
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