Delivery of 100%, 40%, and blow-by humidity did not differ for change in croup scores in children with moderate croup

doi:10.1136/ebm.11.5.142

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Evidence-Based Medicine 2006;11:142; doi:10.1136/ebm.11.5.142
Copyright © 2006 by the BMJ Publishing Group Ltd.

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Therapeutics

Delivery of 100%, 40%, and blow-by humidity did not differ for change in croup scores in children with moderate croup

Scolnik D, Coates AL, Stephens D, et al. Controlled delivery of high vs low humidity vs mist therapy for croup in emergency departments: a randomized controlled trial. JAMA 2006;295:1274–80.[Abstract/Free Full Text]

Q In children presenting to the emergency department (ED) with moderate croup, what is the relative effectiveness of 100% humidity with optimally sized water particles, 40% humidity, and humidity delivered by the blow-by technique?

Clinical impact ratings GP/FP/Primary care $*$ $*$ $*$ $*$ $*$ $*$ ${star}$ Respirology $*$ $*$ $*$ $*$ $*$ $*$ ${star}$ Emergencymedicine $*$ $*$ $*$ $*$ $*$ ${star}$ ${star}$

Key Words: croup • emergency service (hospital) • humidity • nebulisers and vaporisers

The first 150 words of the full text of this article appear below.

METHODS
Design: randomised controlled trial.

Allocation: {concealed}^*.

Blinding: blinded (healthcare providers, data collectors, and {data analysts}^*).

Follow up period: 30 and 60 minutes.

Setting: ED at the Hospital for Sick Children, Toronto, Ontario, Canada.

Patients: 140 children 3 months to 10 years of age (mean age 25 mo, 69%boys) who presented with croup lasting $<=$ 1 week and had Westleycroup scores $>=$ 2 out of 17 after a 30 minute rest period. Exclusioncriteria were need for immediate nebulised epinephrine or intubation,potential alternative cause of stridor, history of intubation,chronic systemic or pulmonary disease other than asthma, useof glucocorticoids in the previous 48 hours or epinephrine inthe previous 4 hours, or non-English speaking caregivers.

Intervention: children were allocated to 100% humidity using a special apparatusto control droplet size (n = 46), 40% relative humidity (n =46), or blow-by humidity (placebo) (n = 48). The . . . [Full text of this article]

Peter C Wyer, MD

Columbia University College of Physicians & Surgeons,
New York, New York, USA

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Glossary
Evid. Based Med. 2006 11: 159a. (in Glossary) [Extract] [Full Text] [PDF]