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Calcium did not prevent fractures in elderly women

Clinical impact ratings GP/FP/Primary care Public health Geriatrics

Key Words: calcium carbonate • dietary supplements • fractures (bone)

The first 150 words of the full text of this article appear below.

METHODS
Design: randomised, placebo controlled trial.

Allocation: concealed.^*

Blinding: blinded {patients, healthcare providers, data collectors, and outcome assessors}.^*

Follow up period: 5 years.

Setting: population-based study in Western Australia.

Participants: 1460 ambulatory women >70 years of age (mean age 75 y) who were not taking any medication affecting bone mass and were expected to survive >5 years.

Intervention: calcium carbonate, 600 mg twice daily with meals (n = 730), or placebo (n = 730).

Outcomes: incident atraumatic clinical fractures and symptomatic vertebral fractures (self reported and confirmed by radiographic reports), and adverse events requiring medical attention.

Patient follow up: 84% completed the study (100% included in the intention to treat analysis).

MAIN RESULTS
A total of 236 women sustained 297 new osteoporotic fractures. Calcium did not reduce the incidence of fractures overall or at any individual site (table). In the 57% of women who were compliant (80% of tablets taken) . . . [Full text of this article]

Sophie A Jamal, MD

University of Toronto,
Toronto, Ontario, Canada

Relevant Article

Glossary
Evid. Based Med. 2006 11: 159a. (in Glossary) [Extract] [Full Text] [PDF]

This article has been cited by other articles:

				Correction Evid. Based Med., June 1, 2007; 12(3): 92 - 92. [Full Text] [PDF]