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Review: computed tomographic colonography is accurate for medium and large colorectal polyps and cancer

Clinical impact ratings Internal medicine Gastroenterology Oncology Surgery—colorectal

Key Words: colonic polyps • colonography (computed tomographic) • colorectal neoplasms

The first 150 words of the full text of this article appear below.

METHODS
Data sources: Medline (1994–2003); EMBASE/Excerpta Medica, Science Citation Index, Cochrane Controlled Trials Register, and relevant key journals (1994 to May 2003); and reference lists of included studies.

Study selection and assessment: full reports in any language of cohort studies that evaluated the use of CTC for the detection of colorectal polyps; used full bowel preparation, prone and supine images, helical scanners, and commercially available software; and blinded interpreters to the results of the reference standard (colonoscopy or surgical findings). Studies with <30 patients or a high proportion of patients with known abnormality were excluded. 24 studies (n = 4181) met the selection criteria. 23 studies involved symptomatic or high risk patients; 1 study involved unselected asymptomatic patients.

Outcomes: pooled sensitivity and specificity on a per patient basis and pooled sensitivity on a per polyp basis for detection of large polyps, medium and large polyps (>5 mm), or any size polyps; . . . [Full text of this article]

Michael J Solomon, MB BCh, Sarah J Lord, MBBS, Silke Walleser, MPH

University of Sydney,
Sydney, New South Wales, Australia