EBM notebook

Jottings...

Paul Glasziou, MBBS, PhD

University of Oxford
Oxford, UK

The first 150 words of the full text of this article appear below.

Most of the articles we pick for EBM stand the test of time, and conclusions are rarely changed by subsequent research. However, John Ioannidis has published a fascinating study of this issue by looking at 49 highly cited articles (>1000 citations) from 1990–2003 ( JAMA 2005;294:218–28[Abstract/Free Full Text] ). Of these, 7 were contradicted by subsequent research, but 5 of these were non-randomised studies (including vitamin E and hormone therapy), and 2 were surrogate endpoints. And none of these was selected for the EBM journal. Having said that, this issue does contain a minor update. We had previously published a trial showing no benefit of antibiotics in conjunctivitis, but the meta-analysis in this issue shows a small benefit.

For those keen on teaching evidence-based medicine, one of the premier events on the international calendar is the biennial meeting in Sicily. So you might like to mark in . . . [Full text of this article]

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