Long term dietary use of potassium enriched salt reduced cardiovascular death in elderly men

doi:10.1136/ebm.11.6.172

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Evidence-Based Medicine 2006;11:172; doi:10.1136/ebm.11.6.172
Copyright © 2006 by the BMJ Publishing Group Ltd.

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Therapeutics

Long term dietary use of potassium enriched salt reduced cardiovascular death in elderly men

Chang HY, Hu YW, Yue CS, et al. Effect of potassium-enriched salt on cardiovascular mortality and medical expenses of elderly men. Am J Clin Nutr 2006;83:1289–96.[Abstract/Free Full Text]

Q In elderly men, does long term use of potassium enriched salt in the diet reduce cardiovascular death?

Clinical impact ratings GP/FP/Primary care $*$ $*$ $*$ $*$ $*$ ${star}$ ${star}$ IM/Ambulatory care $*$ $*$ $*$ $*$ $*$ $*$ ${star}$ Geriatrics $*$ $*$ $*$ $*$ $*$ $*$ ${star}$ Public health $*$ $*$ $*$ $*$ $*$ $*$ ${star}$

Key Words: cardiovascular diseases • potassium chloride

The first 150 words of the full text of this article appear below.

METHODS
Design: cluster randomised controlled trial.

Allocation: unclear allocation concealment.^*

Blinding: blinded (participants).^*

Follow up period: mean 31 months.

Setting: 5 kitchens in a veteran retirement home in northern Taiwan,China.

Patients: 1981 elderly men 40 to $>=$ 80 years of age (mean age 75 y) wereincluded in the analysis. Participants with serum creatinineconcentrations $>=$ 3.5 mg/dl were excluded.

Intervention: 2 kitchens (n = 768) were allocated to gradually increasingconcentrations of potassium enriched salt (49% sodium chloride,49% potassium chloride, and 2% additives). Potassium enrichedsalt was mixed with regular salt in a 1:3 ratio for the firstweek, 1:1 in the second week, 3:1 in the third week, and 1:0beyond the third week. 3 kitchens (n = 1213) were allocatedto regular salt (99.6% sodium chloride and 0.4% additives) atall times.

Outcome: cardiovascular death (due to hypertension, ischaemic heart disease,cerebrovascular disease, heart failure, or diabetes).

Patient . . . [Full text of this article]

Chirag Parikh, MD, PhD, Steven Coca, DO

Yale University School of Medicine,
New Haven, Connecticut, USA

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Evid. Based Med. 2006 11: 191. (in Glossary) [Extract] [Full Text] [PDF]