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Esomeprazole did not universally improve asthma outcomes in moderate to severe stable asthma

Clinical impact ratings GP/FP/Primary care IM/Ambulatory care Gastroenterology Respirology

Key Words: asthma • gastro-oesophageal reflux • omeprazole

The first 150 words of the full text of this article appear below.

METHODS
Design: randomised, placebo controlled trial.

Allocation: {concealed^*}.

Blinding: blinded {patients, healthcare providers, data collectors, outcome assessors, data analysts, monitoring committee, and manuscript writers}.^*

Follow up period: 16 weeks.

Setting: 122 centres in North and South America and Europe.

Patients: 770 patients 18–70 years of age (mean age 45 y, 70% women) with stable, adequately treated asthma, FEV₁ 50–80% of predicted with 12% reversibility, and mean morning peak expiratory flow (PEF) <80% predicted. Exclusion criteria included recent use of a proton pump inhibitor and recurrent moderate to severe symptoms of gastro-oesophageal reflux disease (GORD) in patients >40 years of age. During the run in period, patients were excluded if they had >20% decrease in FEV₁, or severe exacerbations of GORD or nocturnal respiratory (NOC) or asthma symptoms. Patients were stratified into those with NOC (n = 201), GORD (n = 219), or both NOC and GORD (n . . . [Full text of this article]

Brian Smith, MD

The Queen Elizabeth Hospital, Adelaide, South Australia, Australia

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Glossary
Evid. Based Med. 2006 11: 191. (in Glossary) [Extract] [Full Text] [PDF]