Therapeutics
Review: omalizumab reduces exacerbation and steroid use in chronic asthma
Walker S, Monteil M, Phelan K, et al. Anti-IgE for chronic asthma in adults and children. Cochrane Database Syst Rev. 2006;(2):CD003559.
Q In adults and children with chronic asthma, is omalizumab (a recombinant humanised monoclonal anti-IgE referred to as rhuMAb-E25, rhu-Mab, or Xolair) better than placebo for clinical outcomes?
Respirology Paediatrics Allergy & immunology
Key Words: antibodies (anti-idiotypic) • antibodies (monoclonal) • asthma
| The first 150 words of the full text of this article appear below. |
Data sources:
Cochrane Airways Group Asthma and Wheeze trials register (up to February 2006), reference lists of relevant studies and review articles, all pharmaceutical companies producing anti-IgE formulations, 2 websites (www.fda.gov and www.clinicalstudyresults.org), meeting abstracts, and experts in the field.
Study selection and assessment:
randomised and blinded controlled trials (RCTs) in any language that included adults and children with chronic asthma and compared anti-IgE at any dose or route with placebo. 14 RCTs (n = 3143) met the selection criteria. Quality assessment of individual RCTs was based on Jadad scores. All of included RCTs had fair to high quality.
Outcomes:
reduction or termination of steroid (inhaled, oral, or both) use from baseline or run-in period, and asthma exacerbation (defined by hospital admissions, emergency room visits, days lost from work or school, unscheduled doctor visits, or increase in medication).
Omalizumab reduced asthma exacerbations, hospital admission, and some types of
King’s College School of Medicine,
London, UK
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