Therapeutics
Review: long acting ß2 adrenoceptor agonists are effective in poorly reversible chronic obstructive pulmonary disease
Appleton S, Poole P, Smith B, et al. Long-acting beta2-agonists for poorly reversible chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2006(3):CD001104.[Medline]
Q In patients with chronic obstructive pulmonary disease (COPD) and poor reversibility to short acting bronchodilators, how effective are long acting ß2 adrenoceptor agonists (LABAs)?
IM/Ambulatory care Respirology
Key Words: adrenergic beta-agonists • albuterol • bronchodilator agents • ethanolamines • lung diseases (obstructive)
| The first 150 words of the full text of this article appear below. |
Data sources:
Medline, EMBASE/Excerpta Medica, CINAHL, Cochrane Central Register of Controlled Trials, Cochrane Airways Group Specialised Register (to July 2005), online registries of published and unpublished clinical trials, lists of conference abstracts, and bibliographies of relevant studies.
Study selection and assessment:
randomised controlled trials (RCTs) that compared inhaled LABAs (salmeterol or formoterol) given for 
4 weeks with placebo in patients who had stable, moderately severe COPD without asthma; FEV1 
75% or FEV1/FVC 70% of predicted value; poor reversibility after short dose short acting ß2 agonist (15% reversibility of FEV1 from baseline or as a percentage of predicted normal value); and no infections, exacerbations, or hospital admissions in the past month. Individual study quality was assessed using the 5 point Jadad scale. 23 RCTs (n = 6061, mean age range 58–72 y) met the selection criteria and had Jadad scores between 3 and 5.
Outcomes:
lung function (FEV1,
University of Miami, Miller School of Medicine,
Miami, Florida, USA
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