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Environmental and dietary interventions in the first 5 years of life did not reduce risk of asthma and allergic disease

Clinical impact ratings GP/FP/Primary care Allergy & immunology Paediatrics

Key Words: asthma

The first 150 words of the full text of this article appear below.

METHODS
Design: randomised, 2x2 factorial design, placebo controlled trial.

Allocation: {concealed^*}.

Blinding: blinded {participants [diet intervention only], outcome assessors, and laboratory staff}.^*

Follow up period: 5 years.

Setting: {antenatal clinics of 6 hospitals in Sydney, Australia.}

Participants: 616 pregnant women (mean age 29 y), whose unborn singleton child was at increased risk of developing asthma because of asthma or frequent wheezing in a first degree relative. Exclusion criteria included a cat in the home and a vegetarian diet. Infants born at <36 weeks’ gestation, with birth weight <2.5 kg or significant congenital malformation or neonatal disease were withdrawn.

Interventions: active HDM intervention (n = 308), consisting of an allergen impermeable barrier on the child’s bed and pillow, regular washing of bedding, and use of a benzyl benzoate containing solution in the wash every 3 months; or control HDM (n = 308), consisting of usual care. Active . . . [Full text of this article]

Thomas M Ball, MD, MPH

University of Arizona, Tucson, Arizona, USA

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Evid. Based Med. 2007 12: 31-32. (in ) [Extract] [Full Text] [PDF]