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Review: tissue transglutaminase test is almost as accurate as endomysial antibody test for diagnosis of coeliac disease

Clinical impact ratings IM/Ambulatory care Gastroenterology Paediatrics

Key Words: coeliac disease

The first 150 words of the full text of this article appear below.

METHODS
Data sources: PubMed, Medline, Ovid (September 2005), and reference lists.

Study selection and assessment: published, peer reviewed studies in English that evaluated both the EMA and tTG tests in the same untreated patients and controls (adults or children). Coeliac disease had to be confirmed by histology of small bowel biopsy, with the criteria for diagnosis provided (partial or more severe villous atrophy in most studies). Biopsy was not required in controls, but the study had to state how many were biopsy negative and how many were not biopsied (87% of controls were biopsied). 34 studies (n = 12 930) met the selection criteria. 2 sources of antigen were used for the tTG test (guinea pig and human recombinant); some studies evaluated >1 type of tTG test.

Outcomes: sensitivity, specificity, and likelihood ratios pooled from individual patient data.

MAIN RESULTS
Both the EMA and the tTG tests were highly accurate for diagnosis of . . . [Full text of this article]

Amol S Rangnekar, MD, William D Chey, MD, AGAF, FACG

University of Michigan Hospital, Ann Arbor, Michigan, USA