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Review: evidence from 2 low quality screening studies does not show a reduction in death from prostate cancer

Clinical impact ratings GP/FP/Primary care IM/Ambulatory care Oncology

Key Words: mass screening • physical examination • prostate-specific antigen • prostatic neoplasms

The first 150 words of the full text of this article appear below.

METHODS
Data sources: PROSTATE register (up to November 2004), Cochrane Central Register of Controlled Trials, Medline, EMBASE/Excerpta Medica, CANCERLIT, NHS EED (all from 1966 to January 2006); hand searches of specialist journals: BJU International (2000–2005), European Urology (2002–2005), The Prostate (1998–2005), Journal of Urology (1996–2005), Urology (2002–2005), and Cancer (1998–2005); grey literature; and personal communication.

Study selection and assessment: randomised controlled trials (RCTs) and quasi-randomised controlled trials (quasi-RCTs) in any language that compared screening with no screening for prostate cancer in men of any age. Screening procedures included digital rectal examination, prostate specific antigen test, or transrectal ultrasound biopsy. Studies evaluating the economic impact of screening for prostate cancer were also included. 1 RCT (n = 46 486) and 1 quasi-RCT (n = 9026) met the selection criteria. Quality assessment of individual studies was based on randomisation, blinding, completeness of the follow up, and intention to screen analysis. Both included studies . . . [Full text of this article]

Michael J Barry, MD

Harvard Medical School
Boston, Massachusetts, USA