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Evidence-Based Medicine 2007;12:41; doi:10.1136/ebm.12.2.41
Copyright © 2007 by the BMJ Publishing Group Ltd.
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Therapeutics

Vaccinating infants with a wide long needle was non-inferior to a narrow short needle for immune response

Diggle L, Deeks JJ, Pollard AJ. Effect of needle size on immunogenicity and reactogenicity of vaccines in infants: randomised controlled trial. BMJ 2006;333:571.

Q Is vaccination of infants with a wide long needle non-inferior to a narrow short needle for immune response and local reactions?

Clinical impact ratings Paediatrics ******* Infectious disease ******{star} Public health ******{star}

Key Words: diphtheria tetanus pertussis vaccine • drug eruptions • haemophilus vaccines • needles • vaccination

The first 150 words of the full text of this article appear below.

METHODS
Formula Design: randomised controlled non-inferiority trial.

Formula Allocation: concealed.*

Formula Blinding: blinded (data entry clerks and laboratory staff).*

Formula Follow up period: 3–4.5 months.

Formula Setting: 18 general practices in 2 primary care trusts in the UK.

Formula Participants: 696 healthy infants due to receive their first immunisation (mean age 62 d, mean weight 5300 g, 52% boys). Exclusion criteria were <37 weeks gestation, birth weight <2500 g, or treatments or conditions that could bias evaluation of immune response.

Formula Intervention: infants were allocated to vaccination with a 23 gauge, 25 mm needle (wide long needle, n = 240); a 25 gauge, 16 mm needle (narrow short needle, n = 230); or a 25 gauge, 25 mm needle (narrow long needle, n = 226). At 2, 3, and 4 months of age, infants received a combined diphtheria, pertussis, tetanus, and Haemophilusinfluenzae type b vaccine administered into the right thigh and a meningococcal C vaccine into the . . . [Full text of this article]

Manjula Datta, MD

The Tamilnadu Dr. MGR Medical University
Chennai, India


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Evid. Based Med. 2007 12: 63-64. (in ) [Extract] [Full Text] [PDF]





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