Therapeutics
Vaccinating infants with a wide long needle was non-inferior to a narrow short needle for immune response
Diggle L, Deeks JJ, Pollard AJ. Effect of needle size on immunogenicity and reactogenicity of vaccines in infants: randomised controlled trial. BMJ 2006;333:571.
Q Is vaccination of infants with a wide long needle non-inferior to a narrow short needle for immune response and local reactions?
Infectious disease 
Public health
Key Words: diphtheria tetanus pertussis vaccine • drug eruptions • haemophilus vaccines • needles • vaccination
| The first 150 words of the full text of this article appear below. |
Design:
randomised controlled non-inferiority trial.
Allocation:
concealed.*
Blinding:
blinded (data entry clerks and laboratory staff).*
Follow up period:
3–4.5 months.
Setting:
18 general practices in 2 primary care trusts in the UK.
Participants:
696 healthy infants due to receive their first immunisation (mean age 62 d, mean weight 5300 g, 52% boys). Exclusion criteria were <37 weeks gestation, birth weight <2500 g, or treatments or conditions that could bias evaluation of immune response.
Intervention:
infants were allocated to vaccination with a 23 gauge, 25 mm needle (wide long needle, n = 240); a 25 gauge, 16 mm needle (narrow short needle, n = 230); or a 25 gauge, 25 mm needle (narrow long needle, n = 226). At 2, 3, and 4 months of age, infants received a combined diphtheria, pertussis, tetanus, and Haemophilusinfluenzae type b vaccine administered into the right thigh and a meningococcal C vaccine into the
The Tamilnadu Dr. MGR Medical University
Chennai, India
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Evid. Based Med. 2007 12: 63-64. (in )[Extract] [Full Text] [PDF]
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