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Evidence-Based Medicine 2007;12:50; doi:10.1136/ebm.12.2.50
Copyright © 2007 by the BMJ Publishing Group Ltd.

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Therapuetics

A lifestyle intervention continued to prevent type 2 diabetes in high risk patients after the programme was stopped

Lindström J, Ilanne-Parikka P, Peltonen M, et al. Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study. Lancet 2006;368:1673–9.[CrossRef][Medline]

Q In overweight patients with impaired glucose tolerance, are the benefits of a lifestyle intervention for preventing type 2 diabetes maintained after the programme is stopped?

Clinical impact ratings GP/FP/Primary care ******{star} IM/Ambulatory care ******{star} Endocrine ******{star}

Key Words: diabetes mellitus (type 2) • diet • exercise • lifestyle

The first 150 words of the full text of this article appear below.

METHODS
Formula Design: randomised controlled trial.

Formula Allocation: unclear allocation concealment.*

Formula Blinding: blinded {study nurse and laboratory staff}{dagger}.*

Formula Follow up period: Median 7 years (median 3 y postintervention).

Formula Setting: 5 centres in Finland.

Formula Patients: 522 patients {40–65 years of age}{dagger} (mean age 55 y, 67% women) with {body mass index >=25 kg/m2}{dagger} (mean 31 kg/m2) and impaired glucose tolerance {(plasma glucose level 140–200 mg/dl [7.8–11.0 mmol/l] 2 h after a 75 g oral glucose tolerance test and fasting plasma glucose level <140 mg/dl [7.8 mmol/l])}{dagger} on 2 occasions. Exclusion criteria included {previous diagnosis of diabetes and life expectancy <6 y}{dagger}.

Formula Intervention: lifestyle intervention, involving a median 20 individual dietary counselling sessions with a nutritionist and advice to increase physical activity, including the opportunity to participate in individualised training sessions, continued for a median 4 years (n = 265), or general oral and written information about diet and exercise (control) . . . [Full text of this article]

Frank Sullivan, PhD, FRCP, FRCGP

University of Dundee, Dundee, UK


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Evid. Based Med. 2007 12: 63-64. (in ) [Extract] [Full Text] [PDF]






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