Therapuetics
Review: pioglitazone does not reduce risk of mortality or cardiovascular events in type 2 diabetes
Richter B, Bandeira-Echtler E, Bergerhoff K, et al. Pioglitazone for type 2 diabetes mellitus. Cochrane Database Syst Rev 2006;(4):CD006060.
Q In patients with type 2 diabetes, does pioglitazone reduce cardiovascular events, other adverse events, and mortality or improve health related quality of life?
IM/Ambulatory care Cardiology Endocrine
Key Words: diabetes mellitus (type 2) • hypoglycemic agents • thiazolidinediones
| The first 150 words of the full text of this article appear below. |
Data sources:
Cochrane Library (issue 3, 2006), Medline, EMBASE/Excerpta Medica (to August 2006), Controlled Clinical Trials, and reference lists.
Study selection and assessment:
randomised controlled trials (RCTs) 
24 weeks in duration that evaluated pioglitazone in adults with type 2 diabetes. 22 RCTs (n = 12 466, mean age range 54–64 y) met the selection criteria: pioglitazone v placebo (4 RCTs) or another oral antidiabetic medication (13 RCTs), or pioglitazone combined with other oral medications or insulin v another combination of oral medications or insulin (7 RCTs). Assessment of methodological quality included randomisation method, allocation concealment, blinding, intention to treat analysis, and dropouts.
Outcomes:
mortality, morbidity, adverse events, health related quality of life, costs, and metabolic control.
The duration of follow up was 6–12 months in all but 1 RCT. Mortality and major morbidity events were reported by only 1 RCT that compared pioglitazone plus other glucose lowering drugs with placebo
Zena and Michael A Weiner Cardiovascular Institute
New York, New York, USA
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