Therapeutics
Herbal supplements did not relieve vasomotor symptoms of menopause in women
Newton KM, Reed SD, LaCroix AZ, et al. Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial. Ann Intern Med 2006;145:869–79.
Q Do herbal supplements relieve vasomotor symptoms of menopause in women?
IM/Ambulatory care
Key Words: hot flashes • plant preparations • vasomotor system • cimicifuga • estrogen replacement therapy • phytotherapy • soy foods
| The first 150 words of the full text of this article appear below. |
Design:
randomised placebo controlled trial (Herbal Alternatives for Menopause Trial [HALT]).
Allocation:
concealed.*
Blinding:
blinded (clinicians, participants, {data collectors, and outcome assessors}
).*
Follow up period:
12 months.
Setting:
Washington State, USA.
Patients:
351 women 45–55 years of age (mean age 52 y, 93% white) who were in menopausal transition or postmenopausal with 
2 vasomotor symptoms per day for 2 weeks (6 moderate to severe symptoms). Exclusion criteria included contraindications to hormone therapy (HT), use of HT or oral contraceptives in the past 3 months, use of herbal medicines in the past month, bilateral oophorectomy, or history of breast cancer.
Intervention:
black cohosh (Actaea racemosa or Cimicifuga racemosa), 160 mg/day, triterpene glycosides, 2.5%, and ethanol extract, 70% (n = 80); multibotanical (MB) (n = 76); MB plus dietary soy (n = 79); conjugated equine oestrogen (CEO), 0.625 mg/day, with (uterus) or without (no uterus) medroxyprogesterone acetate (MPA),
Brody School of Medicine, East Carolina University,
Greenville, North Carolina, USA
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
- Full Text
- Full Text (PDF)
- web only appendix
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
-
Menopause (including HRT)
-
Complementary medicine
-
Clinical trials (epidemiology)
-
Drugs: cardiovascular system
-
Venous thromboembolism
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
