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Evidence-Based Medicine 2007;12:84; doi:10.1136/ebm.12.3.84
Copyright © 2007 by the BMJ Publishing Group Ltd.
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Therapeutics

Review: eradication therapy supplemented by probiotics increased eradication rates and reduced side effects in H pylori infection

Tong JL, Ran ZH, Shen J, et al. Meta-analysis: the effect of supplementation with probiotics on eradication rates and adverse events during Helicobacter pylori eradication therapy. Aliment Pharmacol Ther 2007;25:155–68.[Medline]

Q In patients with Helicobacter pylori infection, do probiotics improve eradication rates and reduce side effects of anti-H pylori treatment?

Clinical impact ratings Gasterenterology ******{star} Infectious disease *****{star}{star}

Key Words: helicobacter pylori • probiotics

The first 150 words of the full text of this article appear below.

METHODS
Formula Data sources: PubMed, EMBASE/Excerpta Medica, Science Citation Index, and Chinese Biomedical Database (all to October 2006); Cochrane Controlled Trials Register (Issue 2, 2006); reference lists of retrieved articles; abstracts of major gastroenterological meetings; and authors in the field.

Formula Study selection and assessment: randomised controlled trials (RCTs) published in English or Chinese that compared an eradication regimen consisting of proton pump inhibitors and 2 antibiotics plus probiotics with the same eradication regimen plus placebo or no additional treatment in patients of any age who had never been treated for H pylori infection, with confirmation of eradication >=4 weeks after therapy by histology or 13C-urea breath test. Studies evaluating these regimens as second line treatment for previous eradication failure were included. 14 RCTs (n = 1671) met the selection criteria. Quality of individual studies was assessed with the 5 point Jadad scale.

Formula Outcomes: H pylori eradication rates and side effects.

MAIN RESULTS
Meta-analysis . . . [Full text of this article]

Paul Moayyedi, MD

McMaster University,
Hamilton, Ontario, Canada






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