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Review: Framingham risk scores have variable accuracy in predicting CVD events in different patient populations

Clinical impact ratings GP/FP/Primary care Cardiology Internal medicine

Key Words: cardiovascular diseases

The first 150 words of the full text of this article appear below.

METHODS
Data sources: Medline, EMBASE/Excerpta Medica, Cochrane Controlled Trials Register (CENTRAL), CINAHL, PsycINFO, ISI Proceedings, British Library’s Electronic Table of Contents (ZETOC), bibliographies of relevant studies, and hand searches of key journals (to September 2004).

Study selection and assessment: studies in any language that compared risk of fatal and non-fatal coronary heart disease (CHD) or CVD outcomes predicted by Framingham risk scores with observed 10 year risk, and randomised controlled trials (RCTs) that assessed the effectiveness of CV risk scores to aid primary prevention in patients predominantly free of symptomatic CVD. Studies of older risk scores not used in clinical practice and studies reporting only fatal outcomes were excluded. 27 risk assessment studies (n = 71 727, age range 30–80 y) met the selection criteria: 8 studies evaluated the Wilson Framingham method, and 19 evaluated the Anderson Framingham method. The year of initiation of study recruitment ranged from 1961–1996. 4 RCTs . . . [Full text of this article]

Edward P Havranek, MD

Denver Health Medical Center,
Denver, Colorado, USA