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Therapeutics |
Clinical impact ratings GP/FP/Primary care
Infectious disease Tropical & travel medicine
Key Words: circumcision (male) • HIV infections
| The first 150 words of the full text of this article appear below. |
METHODS
Design:
randomised controlled trial.
Allocation:
{concealed*}
.
Blinding:
{blinded (outcome assessors)}.*
Follow up period:
median 24 months.
Setting:
Kisumu district, Kenya.
Participants:
2784 men who were 18–24 years of age (median age 20 y), were HIV negative and sexually active (median 4 partners over lifetime), had haemoglobin concentrations 
90 g/l, and planned to stay in the Kisumu district for 2 years. Exclusion criteria: foreskin covered less than half the glans, haemophilia or other bleeding disorder, high prothrombin time index, contraindications to surgery, or absolute indication for circumcision.
Intervention:
circumcision (n = 1391) or delayed circumcision (control; n = 1393). Surgery was done under local anaesthesia in the study clinic, and men were given verbal and written instructions on postoperative wound care. Participants were advised to avoid sexual activity for 30 days.
Outcomes:
positive result on 2 different HIV tests and adverse effects.
Patient follow up:
91% (intention to
Guy de Bruyn, MBBCh MPH
University of the Witwatersrand,
Johannesburg, South Africa
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