Therapeutics
Review: flight times >8 hours and presence of risk factors for VTE increases travel related VTE
Philbrick JT, Shumate R, Siadaty MS, et al. Air travel and venous thromboembolism: a systematic review. J Gen Int Med 2007;22:107–14.[CrossRef][Medline]
Q What are the risk factors for travel related venous thromboembolism (VTE)? Which preventive treatments are effective?
Haematology IM/Ambulatory care Tropical & travel Medicine
Key Words: air craft • pulmonary embolism • travel • venous thrombosis
| The first 150 words of the full text of this article appear below. |
Data sources:
Medline (1966 to December 2005), Cochrane Central Register of Controlled Trials, Database of Abstracts of Reviews of Effects, and bibliographies of relevant studies.
Study selection and assessment:
case control or cohort studies and randomised controlled trials (RCTs) that evaluated any form of travel as a risk factor of VTE or preventive measures for travel related VTE. Case reports, abstracts, and subgroup analyses of previously published studies were excluded. 25 studies met the selection criteria: 6 case control studies (n = 207–988), 10 cohort studies (n = 320 to >135 million), and 9 RCTs (n = 186–833); most studies evaluated air travel. The interventions evaluated in the 9 RCTs were low molecular weight heparin, aspirin, graduated compression stockings (12–30 mm Hg at the ankle), and herbal remedies with putative antithrombotic properties. Quality assessment of individual studies was based on 8 methodological criteria, which included adequate description of patient selection
McMaster University,
Hamilton, Ontario, Canada
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Venous thromboembolism
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- Clinical trials (epidemiology)
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