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Therapeutics
Review: flight times >8 hours and presence of risk factors for VTE increases travel related VTE

https://doi.org/10.1136/ebm.12.4.105

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    Philbrick JT, Shumate R, Siadaty MS, et al. Air travel and venous thromboembolism: a systematic review. J Gen Int Med 2007;22:107–14.
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 Q What are the risk factors for travel related venous thromboembolism (VTE)? Which preventive treatments are effective?

    Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Haematology ★★★★★★☆ IM/Ambulatory care ★★★★★☆☆ Tropical & travel Medicine ★★★★★☆☆

    METHODS

    Embedded ImageData sources:

    Medline (1966 to December 2005), Cochrane Central Register of Controlled Trials, Database of Abstracts of Reviews of Effects, and bibliographies of relevant studies.

    Embedded ImageStudy selection and assessment:

    case control or cohort studies and randomised controlled trials (RCTs) that evaluated any form of travel as a risk factor of VTE or preventive measures for travel related VTE. Case reports, abstracts, and subgroup analyses of previously published studies were excluded. 25 studies met the selection criteria: 6 case control studies (n = 207–988), 10 cohort studies (n = 320 to >135 million), and 9 RCTs (n = 186–833); most studies evaluated air travel. The interventions evaluated in the 9 RCTs were low molecular weight heparin, aspirin, graduated compression stockings (12–30 mm Hg at …

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    Footnotes

    • For correspondence: Dr J T Philbrick, University of Virginia Health Sciences Center, Charlottesville, VA, USA. jtp9b{at}virginia.edu

    • Sources of funding: no external funding.