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Review: lifestyle or pharmacological interventions prevent or delay type 2 diabetes in impaired glucose tolerance

Clinical impact ratings GP/FP/Primary care IM/Ambulatory care Endocrine Obesity—physician

Key Words: diabetes mellitus (type 2) • glucose intolerance • hypoglycaemic agents • lifestyle

The first 150 words of the full text of this article appear below.

METHODS
Data sources: Medline (1966 to July 2006), EMBASE/Excerpta Medica (1980 to July 2006), Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews (Issue 2, 2006), references of relevant articles, and experts in the field.

Study selection and assessment: randomised controlled trials (RCTs) that evaluated an intervention to delay or prevent type 2 DM in persons with impaired glucose tolerance and had an outcome measurement of diabetes. 21 RCTs met the selection criteria, and 17 RCTs (n = 8084, mean age 39–57 y, mean body mass index 24–36 kg/m², mean follow up 0.4–4.6 y) were included in the meta-analysis. Among the 17 RCTs, 8 had quality scores 3 out of 5 on the Jadad scale, and 2 had allocation concealment.

Outcomes: development of type 2 DM and adverse events.

MAIN RESULTS
Meta-analysis using a random effects model showed that both lifestyle interventions (diet, exercise, or both) and pharmacological interventions (oral . . . [Full text of this article]

Sumit Bhagra, MBBS, Steven A Smith, MD

Mayo Clinic,
Rochester, Minnesota, USA