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Evidence-Based Medicine 2007;12:119; doi:10.1136/ebm.12.4.119
Copyright © 2007 by the BMJ Publishing Group Ltd.

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Therapeutics

Stress echocardiography safely classified more patients as low risk of serious CAD than exercise electrocardiography

Jeetley P, Burden L, Stoykova B, et al. Clinical and economic impact of stress echocardiography compared with exercise electrocardiography in patients with suspected acute coronary syndrome but negative troponin: a prospective randomized controlled study. Eur Heart J 2007;28:204–11.[Abstract/Free Full Text]

Q In patients with suspected acute coronary syndrome and a negative cardiac troponin test, is stress echocardiography (SEcho) better than exercise electrocardiography (ExECG) for predicting risk of serious coronary artery disease (CAD)?

Clinical impact ratings Internal medicine ******{star} Cardiology *****{star}{star}

Key Words: angina (unstable) • echocardiography (stress) • electrocardiography • exercise test • costs and cost analysis

The first 150 words of the full text of this article appear below.

METHODS
Formula Design: randomised controlled trial.

Formula Allocation: unclear allocation concealment.*

Formula Blinding: unblinded.*

Formula Follow up period: median 8.7 months.

Formula Setting: hospital in Harrow, Middlesex, UK.

Formula Patients: 433 patients (mean age 61 y, 57% men) with suspected acute coronary syndrome, non-diagnostic ECG, negative cardiac troponin test result, and >=2 risk factors for CAD. Patients with known CAD awaiting revascularisation were excluded.

Formula Intervention: risk of CAD was determined by SEcho using either treadmill or pharmacological testing (n = 215) or ExECG (n = 218) (negative test = low risk, positive test = high risk, and inconclusive test = pretest risk as determined by the Thrombolysis in Myocardial Infarction [TIMI] risk score). The attending physician made management decisions based on the results of the stress tests.

Formula Outcomes: composite cardiac end point (cardiac death, myocardial infarction, or coronary artery revascularisation), proportion of patients assigned to each risk stratum, use of additional diagnostic tests, and total cost of . . . [Full text of this article]

Paul A Heidenreich, MD, MS

VA Palo Alto, Stanford University, Palo Alto, California, USA







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Copyright © 2007 by the BMJ Publishing Group Ltd.