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Diagnosis
Review: heterogeneous studies show that nucleic acid amplification tests accurately rule in but do not rule out TB

https://doi.org/10.1136/ebm.12.4.121

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    Dinnes J, Deeks J, Kunst H, et al. A systematic review of rapid diagnostic tests for the detection of tuberculosis infection. Health Technol Assess 2007;11:1–314.
    OpenUrlPubMedWeb of Science

    
 
 Q In patients who have tuberculosis (TB), what is the accuracy of rapid diagnostic tests?

    Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Infectious disease ★★★★★★☆ Respirology ★★★★★★☆

    METHODS

    Embedded ImageData sources:

    10 healthcare databases and 11 grey literature databases (to Mar 2004), trial registries, meeting abstracts and conference proceedings, Science Citation Index, reference lists, experts, and manufacturers of tests.

    Embedded ImageStudy selection and assessment:

    English language studies that compared a rapid test for detecting pulmonary and extra-pulmonary TB with a reference standard and reported sufficient data to construct a 2 x 2 table. 212 studies (368 data sets) were included. Quality assessment criteria included use of an appropriate gold standard and blinding of test interpretation.

    Embedded ImageOutcomes:

    sensitivity, specificity, and likelihood ratios.

    MAIN RESULTS

    The table shows the results for groups of tests …

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    Footnotes

    • For correspondence: Dr J Dinnes, University of Southampton, UK

    • Source of funding: NHS R&D HTA Programme