Therapeutics
6 or 3 months of anticoagulant therapy did not differ for treatment failure in patients with DVT, PE, or both
Campbell IA, Bentley DP, Prescott RJ, et al. Anticoagulation for three versus six months in patients with deep vein thrombosis or pulmonary embolism, or both: randomised trial. BMJ 2007;334:674.
Q In patients with deep vein thrombosis (DVT), pulmonary embolism (PE), or both, what is the optimum duration of oral anticoagulant therapy?
Haematology
Key Words: anticoagulants • heparin • pulmonary embolism • venous thrombosis • warfarin
| The first 150 words of the full text of this article appear below. |
Design:
randomised controlled trial (RCT).
Allocation:
{concealed}*.
Blinding:
{unblinded}*.
Follow-up period:
1 year.
Setting:
46 hospitals in the UK.
Patients:
810 patients 
18 years of age (mean age 59 y, 53% men, based on 749 patients) with DVT, PE, or both, who were to receive anticoagulant therapy. Exclusion criteria included DVT or PE in the past 3 years; severe DVT or PE requiring embolectomy or thrombolysis; neoplasia in the past 3 years; polycythaemia, thrombocythaemia, homozygous factor V Leiden, lupus anticoagulant, or deficiency of protein C, protein S, or antithrombin; advanced multiple sclerosis, orthopaedic problems of the lower limbs, or prolonged or continuous immobility for other reasons; allergy to heparin or warfarin; need for long term {ie, permanent}* anticoagulant therapy.
Intervention:
6 (n = 414) or 3 months (n = 396) of anticoagulant therapy (heparin for 5 d followed by warfarin).
Outcomes:
death from DVT or PE, treatment failure
Academic Medical Center, Amsterdam, the Netherlands
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