Therapeutics
Ibuprofen was more effective than codeine or acetaminophen for musculoskeletal pain in children
Clark E, Plint AC, Correll R, et al. A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma. Pediatrics 2007;119:460–7.
Q In children with musculoskeletal pain, what is the relative efficacy of ibuprofen, acetaminophen, and codeine?
Emergency medicine 
Paediatric emergency medicine
Key Words: ibuprofen • acetaminophen • codeine • pain • child.
| The first 150 words of the full text of this article appear below. |
Design:
randomised controlled trial.
Allocation:
{concealed}*.
Blinding:
blinded (patients [children and parents], {healthcare providers}*, and data collectors).
Follow up period:
120 minutes.
Setting:
the emergency department of an academic, tertiary care children’s hospital in Ottawa, Ontario, Canada.
Patients:
336 children 6–17 years of age (mean age 12 y, 60% boys) presenting to the emergency department with pain from a musculoskeletal injury to extremities, neck, or back that occurred in the previous 48 hours. Exclusion criteria included contraindication to a study drug, receipt of 1 of the study drugs in previous 4–6 hours, open fracture, and an intravenous line.
Intervention:
ibuprofen, 10 mg/kg (maximum dose 600 mg, n = 112); acetaminophen, 15 mg/kg (maximum dose 650 mg, n = 112); or codeine, 1 mg/kg (maximum dose 60 mg, n = 112).
Outcomes:
change in patient’s self-reported pain (100 mm visual analogue scale [VAS]), number of patients with adequate analgesia
University of Alberta, Edmonton, Alberta, Canada
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Evid. Based Med. 2007 12: 160. (in Glossary)[Extract] [Full Text] [PDF]
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