Therapeutics
A once yearly IV infusion of zoledronic acid prevented fractures in postmenopausal women with osteoporosis
Black DM, Delmas PD, Eastell R, et al. Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med 2007;356:1809–22.
Q In postmenopausal women with osteoporosis, does a once yearly intravenous infusion of zoledronic acid reduce the incidence of fractures?
IM/Ambulatory care Rheumatology Endocrine Geriatrics
Key Words: osteoporosis (postmenopausal) • fractures, bone • zoledronic acid • diphosphonates
| The first 150 words of the full text of this article appear below. |
Design:
randomised placebo controlled trial (Health Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly [HORIZON]).
Allocation:
not concealed.*
Blinding:
blinded (outcome assessors).*
Follow-up period:
36 months.
Setting:
clinics in 25 countries in Europe, North and Latin America, Australia, and Asia.
Patients:
7765 postmenopausal women (mean age 73 y) with a bone mineral density T score 
2.5 at the femoral neck, with or without vertebral fractures, or with a T score 1.5 and 
2 mild or 1 moderate vertebral fractures. Women were grouped as stratum 1 (n = 6113) if they were not taking any other osteoporosis drug or stratum 2 (n = 1652) if they were already taking 1 of a prespecified list of osteoporosis drugs. Exclusion criteria included previous use of parathyroid hormone or sodium fluoride, use of anabolic steroids or growth hormone within 6 months, use of corticosteroids within 12 months, and previous use of strontium.
Intervention:
East Carolina University, Greenville, North Carolina, USA
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Evid. Based Med. 2007 12: 160. (in Glossary)[Extract] [Full Text] [PDF]
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