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Evidence-Based Medicine 2007;12:146; doi:10.1136/ebm.12.5.146
Copyright © 2007 by the BMJ Publishing Group Ltd.
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Therapeutics

10 day sequential therapy was more effective than 10 day triple drug therapy for eradicating Helicobacter pylori infection

Vaira D, Zullo A, Vakil N, et al. Sequential therapy versus standard triple-drug therapy for Helicobacter pylori eradication: a randomized trial. Ann Intern Med 2007;146:556–63.[Abstract/Free Full Text]

Q In patients with dyspepsia or peptic ulcer disease, is 10 day sequential therapy more effective than 10 day triple drug therapy for eradicating Helicobacter pylori infection?

Clinical impact ratings GP/FP/Primary care ******{star} Gastroenterology ******{star} IM/Ambulatory care ******{star}

Key Words: anti-bacterial agents • anti-ulcer agents • dyspepsia • helicobacter infections • gelicobacter pylori • peptic ulcer

The first 150 words of the full text of this article appear below.

METHODS
Formula Design: randomised controlled trial.

Formula Allocation: {concealed}*.{dagger}

Formula Blinding: blinded (patients, investigators, {data collectors, outcome assessors, data analysts, and data safety and monitoring committee}*).{dagger}

Formula Follow-up period: 8 weeks.

Formula Setting: 2 hospitals in Bologna and Rome, Italy.

Formula Patients: 300 patients >=18 years of age (mean age 49 y, 64% women) with dyspepsia or peptic ulcers who had never received treatment for H Pylori infection. Exclusion criteria included use of proton pump inhibitors, H2 receptor antagonists, bismuth preparations, or antibiotics in the past 2 weeks; concomitant use of anticoagulants or ketoconazole and glucocorticoids; Zollinger Ellison syndrome; and surgery of the oesophagus or upper gastrointestinal tract.

Formula Intervention: sequential (n = 150) or standard triple drug therapy (n = 150). Sequential therapy consisted of pantoprazole, 40 mg, amoxicillin, 1 g, and placebo twice daily for 5 days; and pantoprazole, 40 mg, clarithromycin, 500 mg, and tinidazole, 500 mg, twice daily for the next . . . [Full text of this article]

Vincent Wai-Sun Wong, MD1, Francis Ka-Leung Chan, MD2

1 Institute of Digestive Disease, Hong Kong, China
2 The Chinese University of Hong Kong, Hong Kong, China


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Glossary
Evid. Based Med. 2007 12: 160. (in Glossary) [Extract] [Full Text] [PDF]





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