THERAPEUTICS
Rosiglitazone increased heart failure but did not differ from metformin plus sulphonylurea for other CV outcomes at interim analysis
Correspondence to:
Dr P D Home, SCMS-Diabetes Medical School, Newcastle upon Tyne, UK. E-philip.home@newcastle.ac.uk
| The first 150 words of the full text of this article appear below. |
Home PD, Pocock SJ, Beck-Nielsen H, et al. Rosiglitazone evaluated for cardiovascular outcomes—an interim analysis. N Engl J Med 2007;357:28–38.
Clinical impact ratings GP/FP/Primary care 
Cardiology Endocrine Internal medicine
METHODS
Design:randomised controlled trial (RCT) (Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of glycaemia in Diabetes [RECORD] trial).
Allocation:unclear allocation concealment.*
Blinding:blinded (outcome assessors).*
Follow-up period:mean 3.75 years.
Setting:338 centres in 23 countries in Europe and Australasia.
Patients:4458 patients 40–75 years of age (mean age 58 y, 52% men, 99% white, based on 4447 patients) who had type 2 diabetes, body mass index >25 kg/m2, and haemoglobin (Hb) A1c level >7% to 9% while taking maximum doses of MFN or SFU. Exclusion criteria were use of other glucose lowering drugs, hospital admission for major CV events in the past 3 months, planned CV intervention, heart failure (HF), hepatic disease, renal impairment, and uncontrolled hypertension.
Intervention:
RGZ, 4 mg/day plus MFN
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