THERAPEUTICS
Pioglitazone reduced MI and acute coronary syndrome but not other cardiovascular events in patients with type 2 diabetes and previous MI
| The first 150 words of the full text of this article appear below. |
E Erdmann
Dr E Erdmann, Universität zu Köln, Köln, Germany; erland.erdmann@uni-koeln.de
STUDY DESIGN
subgroup analysis of a randomised controlled trial (PROspective pioglitAzone Clinical Trial In macroVascular Events [PROactive]).
{concealed}*.
blinded {patients, investigators, and study personnel}*.
STUDY QUESTION
19 European countries.
subgroup of 2445 patients with type 2 diabetes (age range 35–75 y, 74% men, 99% white), myocardial infarction (MI) 
6 months before randomisation, {and a haemoglobin A1c concentration >6.5% (or local equivalent)}*.
pioglitazone (n = 1230), increased in 15 mg steps from 15 mg to 45 mg over 2 months to maximum tolerable dose, or matching placebo (n = 1215).
composite end points for the subgroup analysis were fatal or non-fatal MI, cardiovascular (CV) death or non-fatal MI, and CV death or non-fatal MI or stroke (all excluding silent MI). The primary end point (from the main study) was time from randomisation to death or first occurrence of non-fatal MI, non-fatal stroke, acute coronary
McMaster University Hamilton, Ontario, Canada
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