THERAPEUTICS
Daily polyethylene glycol over 6 months was effective for chronic constipation
| The first 150 words of the full text of this article appear below. |
J A DiPalma
Dr J A DiPalma, University of South Alabama Digestive Health Centre, Mobile, AL, USA; gastro@usouthal.edu
STUDY DESIGN
randomised placebo-controlled trial.
unclear allocation concealment.*
blinded (not clear who were blinded).*
STUDY QUESTION
50 centres in the US.
306 patients with chronic constipation over the past 3 months (<3 satisfactory stools per wk without laxative use, and 
1 of the following Rome criteria: straining, lumpy or hard stools, or sensation of incomplete evacuation in >25% of defecations) and during a 14-day observation period (<3 satisfactory bowel movements per wk). Exclusion criteria were prior or current treatment with or sensitivity to study medication; use of medications affecting bowel function; irritable bowel syndrome; pregnancy or lactation; past gastrointestinal (GI) surgery; known or suspected GI obstruction; ileus; ascites; or chronic bowel, liver, or cardiopulmonary disorders.
PEG, 17 g (n = 204), or placebo (n = 100) to be mixed in 8 oz of juice or other
Medical University of South Carolina, Charleston, South Carolina, USA
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