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Evidence-Based Medicine 2008;13:5; doi:10.1136/ebm.13.1.5
Copyright © 2008 by the BMJ Publishing Group Ltd.

EBM NOTEBOOK

Research methods journal club: a gentle introduction to imputation of missing values

Rafael Perera

University of Oxford, Oxford, UK

The first 150 words of the full text of this article appear below.

Missing values are a common problem for researchers to deal with. A range of approaches can be used for this—from ignoring them and analysing "complete data" to imputing them through a model involving the observed (non-missing) data. The review by Donders et al 1 introduces the subject by presenting how missing data arise, describing the choices available for dealing with missing data, and arguing in favour of using multiple imputations above other forms of imputation—including ignoring them.

Deciding how to handle missing data will depend on their characteristics: missing not at random (MNAR), missing at random (MAR), and missing completely at random (MCAR). MNAR arises when the reason for missing data depends directly on information that is not observed (eg, income data missing for those with highest income); while MCAR arises when there is no relation between the characteristics of the participant and the missing data (eg, data lost due to . . . [Full text of this article]


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