THERAPEUTICS
Review: thiazolidinediones increase risk of heart failure in type 2 diabetes
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S Singh
Dr S Singh, Wake Forest University School of Medicine, Winston-Salem, NC, USA; sosingh@wfubmc.edu
REVIEW PROCESS
in patients with type 2 diabetes, what is the risk of heart failure (HF) associated with thiazolidinediones (TZDs)?
Medline (January 2003 to September 2006), EMBASE/Excerpta Medica, Google Scholar, Web of Knowledge, Canadian Drug Reaction Monitoring Program, reference lists, and manufacturers for unpublished studies.
randomised controlled trials (RCTs) in any language comparing TZDs (rosiglitazone [RGZ] or pioglitazone) with placebo for 
6 months in patients with type 2 diabetes and HF; cohort or case-control studies comparing TZDs with other oral antidiabetic drugs (with or without insulin) for new-onset HF; and case reports or case series of all adverse drug reactions (HF and pulmonary oedema) of TZDs. {Quality assessment of individual studies was based on the definition of HF and ascertainment of HF outcomes.}* 3 RCTs (n = 10 731), 3 retrospective cohort studies (n = 65 717),
1 University of Southampton Southampton, UK
2 University of Edinburgh Edinburgh, UK
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Drugs: cardiovascular system
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Diabetes
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Unwanted effects / adverse reactions
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Epidemiologic studies
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