THERAPEUTICS
Review: evidence for major benefits and harms of antidiabetic agents for diabetes with heart failure is limited
| The first 150 words of the full text of this article appear below. |
A Johnson
Dr A Johnson, University of Alberta, Edmonton, Alberta, Canada; jeff.johnson@ualberta.ca
REVIEW PROCESS
in patients with heart failure (HF) and diabetes, what is the relation between antidiabetic therapy and morbidity and mortality?
Medline (1966–2007), EMBASE/Excerpta Medica (1980–2007), Cochrane Central Register of Controlled Trials (1991–2007), 5 other databases, reference lists, and experts.
randomised controlled trials (RCTs) or cohort studies evaluating the association between antidiabetic drugs (insulin, metformin [MET], sulphonylurea [SU], and thiazolidinedione [TZD]) and hospital admission or all-cause mortality in patients with HF and diabetes. Quality assessment of individual studies was based on a validated checklist (maximum score 32; scores 
12 indicate acceptable quality). 8 studies met the selection criteria: 1 RCT, 2 posthoc analyses from RCTs, 4 retrospective cohort studies, and 1 prospective cohort study; quality scores ranged from 13–22.
all-cause hospital admission, hospital admission for HF (cardiovascular morbidity), and all-cause mortality. Meta-analysis was not done because of significant statistical heterogeneity
University of Florida, Gainesville, Florida, USA
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