THERAPEUTICS
Both low-dose and micro-dose 17β-oestradiol reduced hot flushes
| The first 150 words of the full text of this article appear below. |
G A Bachmann
Dr G A Bachmann, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA; gloria.bachmann@umdnj.edu
STUDY DESIGN
randomised, placebo-controlled trial.
concealed.*
blinded (patients, healthcare providers, and data collectors).*
STUDY QUESTION
48 centres in the USA.
425 healthy postmenopausal women 
40 years of age (mean age 53 y, mean time since menopause 9 y) who had an average of 7 (mean 10) moderate or severe hot flushes per day for 1 week during screening. Exclusion criteria included abnormal Pap test result, abnormal vaginal bleeding, and a history of thrombophlebitis or thromboembolic disorder.
transdermal patches delivering 0.023 mg/day 17β-oestradiol (E2) plus 0.0075 mg/day levonorgestrel (low-dose group, n = 145), 0.014 mg/day E2 (micro-dose group, n = 147), or no E2 (placebo group, n = 133).
frequency and severity of hot flushes, treatment response (75% or 90% reduction in hot flush frequency), and adverse events.
12 weeks.
84% (intention-to-treat analysis).
MAIN RESULTS
All
Vanderbilt University Medical Center, Nashville, Tennessee, USA
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Menopause (including HRT)
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Drugs: psychiatry
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Dentistry and oral medicine
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Screening (epidemiology)
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Screening (public health)
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