THERAPEUTICS
A probiotic drink prevented diarrhoea and Clostridium difficile infection in older patients taking antibiotics
| The first 150 words of the full text of this article appear below. |
M Hickson
Dr M Hickson, Charing Cross Hospital, London, UK; mary.hickson@imperial.nhs.uk
METHODS
randomised placebo-controlled trial.
concealed.*
blinded (patients, {healthcare providers, data collectors, outcome assessors, and data analysts, and data safety and monitoring committee}
).*
STUDY QUESTION
3 hospitals in London, UK.
135 patients >50 years of age (mean age 74 y, 54% women) who were receiving antibiotics (single or multiple, oral or intravenous) and were able to take food and drinks. Exclusion criteria included diarrhoea on admission or recurrent diarrhoea; bowel pathology that could cause diarrhoea; intake of high-risk antibiotics (ie, clindamycin, cephalosporins, or aminopenicillins) or >2 courses of other antibiotics in the past 4 weeks; severe life-threatening illness; immunosuppression; bowel surgery; artificial heart valve; history of rheumatic heart disease or infective endocarditis; probiotic treatment before admission; and intolerance to lactose or dairy products.
100 g of probiotic yoghurt drink (Actimel, Danone, France) (n = 69) or a sterile milkshake (n = 66)
Jewish General Hospital and McGill University, Montreal, Quebec, Canada
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