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Evidence-Based Medicine 2008;13:47; doi:10.1136/ebm.13.2.47
Copyright © 2008 by the BMJ Publishing Group Ltd.

THERAPEUTICS

Review: vitamin D supplementation decreases all-cause mortality in adults and older people

The first 150 words of the full text of this article appear below.

P Autier

Dr P Autier, International Agency for Research on Cancer, Lyon, France; autierp@iacr.fr


REVIEW PROCESS

Question:

what is the effect of vitamin D supplementation on all-cause mortality?

Search methods:

PubMed, ISI Web of Science (Science Citation Index Expanded), EMBASE/Excerpta Medica, Cochrane Library, and bibliographies of selected studies, reviews, or books (to November 2006).

Study selection and assessment:

principal published reports of randomised controlled trials (RCTs) that assessed the effects of vitamin D supplementation (vitamin D2 [ergocalciferol] or vitamin D3 [cholecalciferol]), taken for any condition, on all-cause mortality. Trials had to randomise participants on an individual (rather than cluster) basis and include sufficient information to allow for calculation of relative risks and 95% CIs for all-cause mortality for vitamin D supplementation v placebo or control. Trials that evaluated treatment with 1{alpha} hydroxyvitamin D3 (alfacalcidol), 1{alpha},25 dihydroxyvitamin D3 (calcitriol), or other vitamin D analogues in patients with advanced prostate cancer, chronic or end stage renal disease, or those on . . . [Full text of this article]

Joel A Simon

San Francisco Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, California, USA


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