THERAPEUTICS
Daily vitamin C prevented development of complex regional pain syndrome in adults with wrist fractures
| The first 150 words of the full text of this article appear below. |
P E Zollinger
Dr P E Zollinger, Ziekenhuis Rivierenland, The Netherlands; pe.zollinger@tiscali.nl
STUDY DESIGN
randomised controlled trial.
{concealed}*.
blinded (patients and physicians).
emergency departments in 3 hospitals in the Netherlands.
STUDY QUESTION
416 patients, 
18 years of age, with 427 wrist fractures (82% in women).
1 of 3 daily doses of vitamin C (200 mg [n = 96 fractures], 500 mg [n = 114], or 1500 mg [n = 118]) or placebo (n = 99), started on the day of the fracture and taken in 2 capsules/day for 50 days.
complex regional pain syndrome (CRPS) type 1 within 1 year after fracture, diagnosed if 4 of the 5 following symptoms were present at or distal to the wrist and occurred or increased after activity: abnormal, unexplained, diffuse pain; difference in skin colour relative to the other hand; difference in skin temperature relative to the other hand; diffuse oedema; or abnormally limited active range of
University of Western Ontario, London, Ontario, Canada
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Neuromuscular disease
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Clinical trials (epidemiology)
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Pain (neurology)
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